Diphenyl ethanolamine salt of penicillin



Patented June 29, 1954 DIPHENYL ETHANOLAMINE SALT OF PENICILLIN William B. .Wheatley, Syracuse, and Joseph T. Alberi, Jamesville, N. Y., assignors to Bristol Laboratories Inc., Syracuse, N. Y., a corporation of New York No Drawing. Application February 16, 1951, Serial No. 211,438

,5-DiphenyZ-B-hydroxyethyla.mine salt of penicillin To .48 g. of a,p-diphenyl-;8-hydroxyethylamine hydrochloride dissolved in 6 ml. of distilled water was added a solution containing 1 g. of sodium penicillin G in 4 ml. of Water. The solution was stirred well and an oil precipitated. On scratching and stirring crystals formed. After standing for half an hour in an ice bath the crystals were filtered off and dried in a. vacuum desiccator.

Assay showed a potency of 1207 u./mg. and a Water solubility of 6630 u./ m1.

We claim:

1. A salt of penicillin G and a,fl-diphenyl-;8- hydroxyethylamine.

2. A salt of penicillin and a,;8-diph y -B droxyethylamine.

References Cited in the file of this patent UNITED STATES PATENTS Number Name Date 2,493,625 Goldberg et al Jan. 3, 1950 2,527,810 Goldberg et al Oct. 31, 1950 

2. A SALT OF PENCILILLIN AND A,B-DIPHENYL-B-HYDROXYETHYLAMINE. 